• Which oil-based ingredients closely resemble our skin's natural sebum?

    Squalane and GTCC (high-purity oil esterified from caprylic/capric acid and glycerol) can be formulated into a compound ingredient known as Plant-Based Bionic Sebum, which is also worth exploring.


  • Should frequent hair loss mean not washing hair often?

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  • What are common whitening agents in cosmetics?

    In recent years, the reduction of ozone in the ozone layer has allowed large amounts of ultraviolet radiation to enter the atmosphere through the ozone hole. When UV rays penetrate the outermost stratum corneum of the skin and reach the inner epidermal layers, tyrosinase in melanocytes becomes activated, producing excessive pigment, which leads to the formation of spots and uneven skin tone. Modern cosmetics have become daily consumer products used to improve skin appearance, pursue fashion, and enhance personal charm. Whitening cosmetics, in particular, are skincare products designed to address hyperpigmentation. The pursuit of safe, gentle, healthy, and effective whitening methods has become a growing trend. The Zhina Technology team will explore commonly used cosmetic whitening agents and the synergistic effects of different whitening ingredients in improving pigmentation.

    Common Whitening Agent Ingredients


    Arbutin and its derivatives
    Arbutin, also known as arbutoside, appears as white needle-like crystals or powder and is readily soluble in water and polar solvents. It can be sourced from plant extraction, plant tissue culture, enzymatic methods, or organic synthesis, with purity being a critical factor in quality evaluation. As a derivative of hydroquinone, arbutin acts as a reversible competitive inhibitor of tyrosinase. It suppresses tyrosinase activity within concentrations non-toxic to melanocytes, blocking the synthesis of dopa and dopaquinone, thereby inhibiting melanin production, reducing skin pigmentation, and fading spots.

    Vitamin C and its derivatives
    Vitamin C, also known as ascorbic acid, exhibits antioxidant properties and free radical-scavenging abilities. Its whitening mechanism primarily involves two aspects: first, it interrupts the oxidation process of melanin and reduces melanin intermediates and polymers; second, it participates in tyrosine metabolism, inhibiting tyrosinase activity to decrease melanin formation and achieve whitening effects. However, due to its susceptibility to oxidation and discoloration in air, as well as poor skin absorption, Vitamin C has increasingly been replaced by derivatives with comparable whitening efficacy but superior stability and absorption. Examples include Magnesium Ascorbyl Phosphate, Ascorbyl Palmitate, and Ascorbyl Glucoside.


     

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    Niacinamide
    Niacinamide acts on existing melanin by accelerating skin cell metabolism, promoting the shedding of melanin-containing keratinocytes, and interfering with melanosome transfer to reduce their migration to surface cells, thereby achieving spot-lightening and whitening effects.

    Tranexamic Acid
    Tranexamic acid primarily whitens by inhibiting tyrosinase and melanocyte activity, reducing already formed melanin, preventing melanin aggregation, and blocking the transfer of melanosomes to keratinocytes. It also suppresses prostaglandin (PGE2), inhibiting melanin formation at its initial stage after UV exposure to prevent pigmentation.

    Licorice Extract
    As a natural plant-based whitening agent, licorice extract has broad market applications due to its rapid, efficient, and safe whitening properties. Its efficacy stems from inhibiting tyrosinase, suppressing dopachrome tautomerase activity, and impeding the polymerization of 5,6-dihydroxyindole. Licorice flavonoids, active components extracted from licorice, strongly absorb both UV and visible light. The extract also demonstrates antioxidant free radical scavenging ability comparable to vitamin E and SOD-like activity.

    Centella Asiatica Extract
    Centella asiatica extract strengthens the connection between the epidermis and dermis, softens the skin, stimulates collagen production in the dermis, and enhances skin firmness and stratum corneum hydration. Functionally, it promotes blood circulation, improves acne-prone skin, prevents pigmentation, boosts collagen synthesis for better skin elasticity, delays skin aging, and proves highly effective in post-UV exposure recovery.



     

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    Formulation Strategy:

    In the biosynthesis of skin melanin, in addition to tyrosinase, dopachrome tautomerase and DHICA oxidase are also involved. Therefore, the compounding principle of whitening agent ingredients should not only consider the structural characteristics of different skin types but also determine the ingredient combination strategy based on the mechanism of melanin formation and various influencing factors in the process. Simultaneously, the synergistic and antagonistic effects between each ingredient must be taken into account.


    Brightening Complex — Derived from Chinese herbal medicine, it gently and rapidly improves dull skin tone and related concerns!

    Brightening Complex is based on the formulation principles of traditional Chinese medicine, selecting licorice, wormwood, and wolfberry to regulate the liver, spleen, and kidneys, supplemented with mulberry root bark to tonify deficiency and boost qi, and scutellaria baicalensis to clear heat and dry dampness. This blend perfectly integrates five botanical active ingredients, leveraging synergistic effects to address pigmented skin concerns. Simultaneously, Brightening Complex is meticulously extracted using modern extraction and separation technologies. Each component in its efficacy system targets key pathways in modern dermatological theory for combating melanin, achieving "simultaneous treatment of root causes and symptoms" and delivering powerful brightening effects through multi-target, multi-dimensional, and multi-level actions.

    Laboratory tests confirm that the compound product exhibits excellent stability and an optimal pH, with user feedback indicating minimal irritation and significant results. As the pursuit of effective brightening products continues to evolve, leveraging the synergy and comprehensive effects of various brightening agent ingredients will serve as the guiding principle for our ongoing development of whitening product formulations.



     

    Disclaimer:

    This article is compiled and published by Zhina Biotechnology.
    Part of the content is sourced from the literature: Exploration of Whitening Agent Combinations in Improving Skin Pigmentation by Yang Yong.

    Some content, images, text, and videos on this site are curated from the internet for learning and communication purposes. No guarantee or commitment is made regarding the authenticity, accuracy, or timeliness of such materials. If you have any concerns regarding potential infringement of your copyright, intellectual property, or portrait rights, please contact us promptly at (021-37561269), and we will review and address the matter accordingly.




  • Why does skin need hydration?

    An Essential Physiological Function of the Skin – Moisturization

    1. The process of skin aging, from infancy to old age, can essentially be described as a process of continuous water loss.

    2. The tenderness of the skin depends on the water content in the stratum corneum of the epidermis, as the skin's moisture level decreases gradiently from the inner to the outer layers.

    3. The normal water content of the stratum corneum is 10–20%. When external humidity drops below 60%, the water content in the stratum corneum decreases, leading to skin issues such as dryness.



    Therefore, hydration is a crucial fundamental step in daily skincare routines.

    Currently, the raw materials for moisturization and hydration offered by Zhina Biotechnology include: Oat β-Glucan and Tamir® Stratum Corneum Hydration Complex H-109.